“Enclomiphene blocks estrogen from interacting with the pituitary glad in our bodies. When estrogen interacts with our pituitary gland less luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced. This leads to a decrease in testosterone. Because Enclomiphene blocks estrogen, there is an increase in LH, FSH and testosterone. Enclomiphene may be an effective alternative to TRT for patients with Low T.